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Synthesis of labelled ecdysone precursors: Part I‐tritium labelled ( 3 H 4 ‐22, 23,24,25)‐3β, 14α‐dihydroxy‐5β‐cholest‐7‐en‐6‐one
Author(s) -
Haag T.,
Hetru C.,
Nakatani Y.,
Luu B.,
Pichat L.,
Audinot M.,
Meister M.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220604
Subject(s) - ecdysone , chemistry , tritium , prothoracic gland , labelling , biosynthesis , radiochemistry , in vitro , chemical synthesis , stereochemistry , biochemistry , hormone , enzyme , physics , nuclear physics
Abstract High specific activity tritiated 3β, 14α ‐dihydroxy‐5β‐cholest‐7‐en‐6‐one, has been prepared using a precursor which permits rapid and easy labelling. This compound is converted to ecdysone under in vitro conditions by insect prothoracic glands, a well known site of ecdysone biosynthesis.