Premium
13 C‐Labelled benzo[a]pyrene and derivatives. An efficient pathway of labelling the 1‐, 2‐, and 3‐positions
Author(s) -
Bodine Richard S.,
Daub Guido H.,
Vanderjagt David
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220509
Subject(s) - chemistry , pyrene , labelling , ketone , lithium (medication) , benzo(a)pyrene , condensation , stereochemistry , organic chemistry , biochemistry , medicine , physics , endocrinology , thermodynamics
Abstract A ten step synthesis of benzo [a]pyrene‐1‐ 13 C, ‐2‐ 13 C, or 3‐ 13 C from 2,3,7,11b‐tetrahydrobenz[d, e] anthracen‐3(1h)‐one is described in which the initial step involves the condensation of this ketone with the lithium enolate of ethyl acetate. This completes our synthesis of the tweleve 13 C labelled benzo[a]pyrenes.