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Preparation and purification of 125 I‐labeled iodospiroperidol
Author(s) -
Landvatter Scott W.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220308
Subject(s) - chemistry , yield (engineering) , acetic acid , specific activity , radiochemistry , iodine , high performance liquid chromatography , chromatography , nuclear chemistry , organic chemistry , enzyme , materials science , metallurgy
Iodine‐125 labeled spiroperidol has been synthesized by a simple, one‐step procedure starting from spiroperidol. This synthesis employs 125 I‐ and H 2 O 2 in buffered acetic acid. This pH dependent reaction affords iodospiroperidol in 40% radiochemical yield and a specific activity, after HPLC purification, of ca. 1900 Ci/mmol.