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Convenient preparation of deuterated uracils and dihydrouracils
Author(s) -
Hill Richard K.,
Ledford N. Dale,
Renbaum Louis A.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220207
Subject(s) - chemistry , uracil , deuterium , urea , medicinal chemistry , combinatorial chemistry , organic chemistry , biochemistry , dna , physics , quantum mechanics
The reaction of [3‐ 2 H 1 ]propiolic acid with urea provides a simple route to [6‐ 2 H 1 ]uracil, and further exchange with DCl affords [5,6‐ 2 H 2 ]uracil. Reaction of the meso and d, 1 ‐isomers of [2,3‐ 2 H 2 ]succinamide with lead tetraacetate leads to the cis and trans isomers of [5,6‐ 2 H 2 ]5,6‐dihydrouracil.