Premium
Resolution of [ 11 C]DL‐leucine and [ 11 C]DL‐tryptophan by high‐performance liouid chromatography
Author(s) -
Washburn Lee C.,
Sun Tan Tan,
Byrd Billy L.,
Callahan Alvin P.
Publication year - 1985
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580220206
Subject(s) - chemistry , tryptophan , high performance liquid chromatography , resolution (logic) , valine , chromatography , leucine , amino acid , biochemistry , artificial intelligence , computer science
High‐performance liquid chromatographic (HPLC) resolution of [ 11 C]DL‐leucine and [ 11 C]DL‐tryptophan, using modifications of a previously developed technique for resolution of [ 11 C]DL‐valine, was used to produce [ 11 C]L‐leucine and [ 11 C]L‐tryptophan. The technique employs commercially available reverse phase HPLC columns and chiral mobile phases containing cupric acetate and L‐proline.