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Synthesis of 11 C‐labelled choline
Author(s) -
Diksic Mirko,
Yamamoto Y. Lucas,
Feindel William
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210905
Subject(s) - chemistry , yield (engineering) , choline , radiochemistry , ethanol , radiosynthesis , organic chemistry , biochemistry , in vivo , materials science , metallurgy , microbiology and biotechnology , biology
We report the synthesis of 11 C‐labelled choline using the reaction of “nocarrier‐added” 11 C‐labelled methyliodide and 2‐amino‐(N,N‐dimethyl)‐ethanol. After determining the optimum temperature and duration for the reaction, we achieved a radiochemical yield of about 30% and the radioactivity levels needed for PET studies in humans.