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The synthesis of α‐methylstyrenes with 14 C‐labelling in the side chain
Author(s) -
Ali H. M.,
Barson C. A.,
Coe P. L.
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210903
Subject(s) - chemistry , labelling , side chain , wittig reaction , methylene , distillation , chain (unit) , radiochemistry , chain reaction , chemical synthesis , organic chemistry , photochemistry , biochemistry , in vitro , physics , astronomy , polymer
α‐Methylstyrenes with all three side chain carbons specifically 14 C‐labelled have been synthesised by Wittig reactions between the appropriately labelled acetophenones or methylene triphenylphosphoranes. The yields in all cases were good and any radiochemical impurities could be readily removed by distillation.