Synthesis of the epimeric 2‐bromocholesterols and their conversion into (2α‐ 3 H)cholesterol and [2ß‐ 3 H]cholesterol | Zendy

Römer J. | Zendy; Wagner H. | Zendy; Ponsold K. | Zendy

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Synthesis of the epimeric 2‐bromocholesterols and their conversion into (2α‐ 3 H)cholesterol and [2ß‐ 3 H]cholesterol

Author(s) -

Römer J.,

Wagner H.,

Ponsold K.

Publication year - 1984

Publication title -

journal of labelled compounds and radiopharmaceuticals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.432

H-Index - 47

eISSN - 1099-1344

pISSN - 0362-4803

DOI - 10.1002/jlcr.2580210810

Subject(s) - chemistry , labelling , cholesterol , catalysis , specific activity , stereochemistry , radiochemistry , medicinal chemistry , organic chemistry , enzyme , biochemistry

The synthesis of the epimeric 2‐bromocholesterols is described. Their reductive catalyzed debromination with T 2 affords [2α‐ 3 H]‐ and [2ß‐ 3 H]cholesterol respectively. The [2‐ 3 H] cholesterols can be synthesised with a radiochemical purity >98% and specific activities of about 600–700 GBq/mmol. The labelling reactions proceed under retention.

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