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Synthesis of tetrachloroisophthalo‐[ 14 C]‐nitrile
Author(s) -
Davies Peter E.
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210309
Subject(s) - nitrile , chemistry , yield (engineering) , cyanide , iodine , radiochemistry , organic chemistry , nuclear chemistry , medicinal chemistry , metallurgy , materials science
A low cost, high yield synthesis of tetrachloroisophthalo‐[ 14 C]‐nitrile (TCIN) is described. Direct replacement of iodine in 3‐iodobenzonitrile using 14 C‐labeled cuprous cyanide, and vapour phase chlorination yields [ 14 C]‐TCIN, with maximum utilisation of the radiolabel. Alternative and unsuccessful routes are also briefly described.