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A simple, rapid synthesis of caffeine‐1,7‐ 13 CH 3
Author(s) -
Pierce W. M.,
Schlager J. J.,
Madden R. J.,
Hurst H. E.
Publication year - 1984
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580210212
Subject(s) - chemistry , yield (engineering) , chemical synthesis , caffeine , combinatorial chemistry , simple (philosophy) , product (mathematics) , radiochemistry , organic chemistry , in vitro , physics , biochemistry , medicine , endocrinology , philosophy , geometry , mathematics , epistemology , thermodynamics
This paper describes a simple, rapid synthesis of caffeine‐1,7‐ 13 CH 3 produced by the reaction of iodomethane‐ 13 C with 3‐methylxanthine. The synthesis is complete in one day, requires only the most rudimentary laboratory equipment, and is amenable to large scale synthesis. Overall yield after product isolation is 82%, and the product is of 99% chemical purity and 99% isotopic purity.