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A total synthesis of [9′, 10′‐ 3 H]‐labelled paf‐acether
Author(s) -
Wichrowski Boguslaw,
Michel Elie,
Heymans Françoise,
Roy Jean,
Morgat JeanLouis,
Godfroid JeanJacques
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200809
Subject(s) - chemistry , acetylation , trimethylamine , glycerol , medicinal chemistry , catalysis , phosphorylation , specific activity , stereochemistry , organic chemistry , biochemistry , enzyme , gene
1‐O‐octadecen‐[9′, 10′]‐yl 2‐o‐benzyl sn‐glycero‐3‐phosrylcholine was obtained from 1‐O‐octadecen‐[9′, 10′]‐yl sn‐glycerol by tritylation, benzylation and phosphorylation with 2‐bromoethyl phosphoryl dichloride followed with trimethylamine reaction. Catalytic tritiation of the double bond led to labelled “lyso” PAF‐acether from which PAF‐acether with a specific radioactivity between 40 and 50 Ci/mmole was obtained by acetylation.