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Synthesis of 14 C‐labelled 1‐methanesulphonyl‐3‐(1‐methyl‐5‐nitro‐1H‐imidazol‐2‐YL)‐2‐imidazolidinone, (Go 10213)
Author(s) -
Anjaneyulu B.,
Maller R. K.,
Nagarajan K.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200805
Subject(s) - chemistry , yield (engineering) , potassium thiocyanate , nitro , thiocyanate , ring (chemistry) , carbon 14 , medicinal chemistry , stereochemistry , nitroimidazole , nitro compound , chemical synthesis , radiochemistry , organic chemistry , in vitro , biochemistry , alkyl , materials science , physics , quantum mechanics , metallurgy
For pharmacokinetic and metabolism studies in animals and humans, Go 10213 was labelled with carbon‐14 at the 2‐position of the 5‐nitroimidazole ring system, in an overall yield of 22% starting with potassium[ 14 C]‐thiocyanate. The labelled compound had a specific activity of 4.65 μCi/mg or 1.34 mCi/mmol.