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Synthesis of 2‐(2,4‐difluorophenyl)‐4,5‐BI‐(4‐methoxyphenyl) [2‐ 14 C] imidazole
Author(s) -
Scott P. W.,
Hawkins D. R.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200503
Subject(s) - chemistry , imidazole , medicinal chemistry , stereochemistry
The synthesis of 2‐(2,4‐difluorophenyl)‐4,5‐bis(4‐methoxyphenyl)imidazole labelled with carbon‐14 in the 2‐position of the imidazole ring has been achieved in four stages starting from barium [ 14 C] carbonate via 2,4‐difluoro‐[ carboxyl ] 14 C benzoic acid and the corresponding aldehyde. The overall radiochemical yield was 20% and the product obtained with a radiochemical purity in excess of 99% by the analytical systems used.