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A novel method for the preparation of adenosine 3′5′ cyclic phosphate labelled with 14 C or 3 H
Author(s) -
Pandey V. N.,
Nair C. K. K.,
Pradhan D. S.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200308
Subject(s) - chemistry , adenosine , guanine , base (topology) , purine , phosphate , stereochemistry , purine metabolism , nucleotide , radiochemistry , biochemistry , enzyme , mathematical analysis , mathematics , gene
High yields of cyclic AMP (cAMP) and cyclic GMP (cGMP) could be obtained by near quantitative conversions of adenine and guanine by aerobically‐grown nonproliferating cells of Corynebacterium murisepticum. The procedure is especially suited for the preparation of 14 C or 3 H labelled cAMP and cGMP from respective purine base precursors.