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Synthesis of 14 C‐labeled surfactants: Sodium p ‐n‐dodecylbenzenesulfonate‐[phenyl‐U‐ 14 C]
Author(s) -
Chien David H. T.,
Duncan William P.
Publication year - 1983
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580200116
Subject(s) - sodium dodecylbenzenesulfonate , chemistry , benzene , yield (engineering) , ketone , acylation , sodium , medicinal chemistry , nuclear chemistry , organic chemistry , catalysis , aqueous solution , materials science , metallurgy
The synthesis of sodium p ‐n‐dodecylbenzenesulfonate‐[phenyl‐U‐ 14 C], III, from benzene‐U‐ 14 C is described. The preparative method consists of simple Friedel‐Crafts acylation, reduction of the resulting ketone, I, and sulfonation of II with chlorosulfonic acid. The specific activity of III was 6.8 mCi/mmole and the overall radiochemical yield was 25% (based on benzene‐U‐ 14 C).