Premium
Synthesis of deuterium‐labelled peptido‐aminobenzophenone [4‐chloro‐2‐(2′‐chlorobenzoyl)‐N‐(glycylglycyl)‐N‐methyl‐anilide] and its metabolites
Author(s) -
Hashimoto Shin'Ichirō,
Takahashi Shirō
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190707
Subject(s) - chemistry , benzodiazepine , deuterium , lorazepam , stereochemistry , biochemistry , anesthesia , medicine , physics , receptor , quantum mechanics
Deuterium‐labelled peptido‐aminobenzophenone [4‐chloro‐2‐(2′‐chlorobenzoyl)‐N‐(glycylglycl)‐N‐methylanilide, 1] and its benzodiazepine‐metabolites were prepared for use as internal standards in the quantification of the peptido‐aminobenzophenone, chlorodiazepam, lormetazepam, chlorodesmethyldiazepam, and lorazepam at low levels in human plasma by selected ion monitoring.