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Direct preparation of 14 C‐labeled 5‐allyl‐ and 5‐propyl‐2′‐deoxyuridine from [2‐ 14 C]2′‐deoxyuridine
Author(s) -
Ruth Jerry L.,
White Steven K.,
Bergstrom Donald E.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190706
Subject(s) - chemistry , deoxyuridine , uridine , deoxyribonucleoside , alkyl , stereochemistry , organic chemistry , rna , biochemistry , dna , enzyme , gene
Abstract [2‐ 14 C]5‐Allyl‐2′‐deoxyuridine was synthesized directly from [2‐ 14 C]2′‐deoxyuridine using mercury, palladium, and 3‐chloropropene. [2‐ 14 C]5‐Propyl‐2′‐deoxyuridine was obtained by hydrogenation of the [ 14 C]5‐allyl‐2′‐deoxy‐uridine. Advantages of the synthetic method and its application to the preparation of other radiolabeled 5‐alkyl/alkeny1‐2′‐deoxyuridines are discussed.