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Partial synthesis of tritium‐labelled gibberellin‐A 3
Author(s) -
Lischewski M.,
Adam G.,
Liebisch H.W.,
Pleiß U.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190604
Subject(s) - gibberellin , chemistry , acetylation , tritium , organic chemistry , radiochemistry , stereochemistry , biochemistry , botany , physics , biology , nuclear physics , gene
The epimeric gibberellin‐A 3 ‐7‐aldehydes 1 and 2 were silylated, enolised with KH and labelled with 3 H 2 O to give after desilylation the tritium‐labelled epimeric gibberellin‐A 3 ‐7‐aldehydes 4 and 5 . Subsequent acetylation, oxidation and deacetylation afforded [6‐ 3 H] gibberellin‐A 3 ( 6 ) and [6‐ 3 H]6‐epi‐gibberellin‐A 3 ( 7 ). Thus, this route provides a convenient method for the preparation of [6‐ 3 H]GA 3 of high specific radioactivity.