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Synthesis of radioactively methyl‐labelled ( l )‐carnitine
Author(s) -
Ingalls Stephen T.,
Hoppel Charles L.,
Turkaly Julia S.
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190408
Subject(s) - chemistry , yield (engineering) , chloride , dimethylformamide , methanol , salt (chemistry) , carnitine , sodium , methylation , chromatography , nuclear chemistry , organic chemistry , biochemistry , dna , materials science , solvent , metallurgy
Commercial ( l )‐carnitine chloride was N‐demethylated by the action of sodium benzenemercaptide in warm N,N‐dimethylformamide. The product 4‐(N,N‐dimethylammonio)‐3‐hydroxybutanoic acid chloride salt was isolated in good yield by ion exchange chromatography. Methylation of the product by 14 C ‐iodomethane in dry methanol produced biologically active 4‐N‐ Me‐ 14 C ‐( l )‐carnitine chloride of high specific activity in excellent yield.