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Synthesis of dimethyl 5, 5, 6, 6 ( 2 H 4 )‐2‐oxoheptylphosphonate, a deuterium labelled prostaglandin intermediate
Author(s) -
Meese Claus O.,
Borstel Bernd
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190405
Subject(s) - chemistry , deuterium , acetylene , prostaglandin , catalysis , radiochemistry , medicinal chemistry , organic chemistry , nuclear physics , biochemistry , physics
The synthesis of the specifically labelled versatile prostaglandin intermediate 1b is described which involves the preparation of 2,2,3,3 ( 2 H 4 )butyliodide 6b via homogenous catalytic deuteration of the acetylene 4 . Examples for the preparation of prostaglandins and extensive spectroscopic data are included.