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The preparation of carbon‐14 and tritium labelled 1‐[4‐(2‐dimethylaminoethoxy)phenyl]‐1, 2‐diphenyl‐1‐butene [ICI 46,474, tamoxifen (‘nolvadex’ )] and the separation of cis‐trans isomers I. The synthesis of carbon‐14 labelled tamoxifen (‘nolvadex’ )
Author(s) -
Burns J,
Rutter D
Publication year - 1982
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580190208
Subject(s) - chemistry , bromobenzene , tritium , chromatographic separation , chromatography , organic chemistry , high performance liquid chromatography , catalysis , physics , nuclear physics
The preparation of [ 14 C]tamoxifen from [U‐ 14 C]bromobenzene is described. Several preparations of the compound have been made with overall radiochemical yields of 12% ‐ 14%, and specific activities 1.3 to 10.1 mCi/mmol have been obtained. The purification procedures used, including the separation of the cis‐trans isomers by preparative thin layer chromatoqraphy, are also described.