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Enzymatic labelling of carcinoembryonic antigen with iodine‐125
Author(s) -
Siuda Andrzej,
Lucka Barbara,
Russin Krystyna
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580181213
Subject(s) - carcinoembryonic antigen , chemistry , lactoperoxidase , labelling , radioimmunoassay , iodine , chromatography , specific activity , antigen , radiochemistry , enzyme , biochemistry , medicine , peroxidase , immunology , organic chemistry , cancer
Carcinoembryonic antigen /CEA/ was labelled with iodine‐125 using lactoperoxidase. The radiochemical yield of / 125 I/CEA was about 25% at the specific activity of about 30μCi/μg /1.1MBq/μg/. The percentage binding of / 125 I/CEA with specific anti‐CEA serum was determined in lyophilized samples during storage. The obtained / 125 I/CEA preparations can be utilized in radioimmunoassay kits for at least two months.