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Synthesis of methionines specifically labelled with 2 H or 13 C
Author(s) -
Billington David C.,
Golding Bernard T.,
Kebbell Michael J.,
Nassereddin Ishaq K.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580181210
Subject(s) - methionine , chemistry , stereochemistry , radiochemistry , amino acid , biochemistry
Efficient methods for synthesising L‐[methy‐ 13 C]methionine from [ 13 C]iodomethane and L‐methionine, and L‐[3,4‐ 13 C 2 ] methionine from [ 13 C 2 ]ethene, are described; the preparation of [3,3‐ 2 H 2 ]methionine and [2,3,3‐ 2 H 3 ]methionine from methionine by an exchange method is detailed.