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Synthesis of 14 C‐labeled inhibitors of monoamine oxidase
Author(s) -
Williams C. H.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580181019
Subject(s) - clorgyline , chemistry , pargyline , monoamine oxidase , monoamine oxidase b , combinatorial chemistry , biochemistry , enzyme
The monoamine oxidase inhibitors pargyline and clorgyline have been synthesized by methylation of the appropriate secondary propargylamines, using [ 14 C]dimethyl sulphate. This simple method should be generally applicable to other compounds of this class.