Premium
Preparation of deuterium labelled catecholamines
Author(s) -
Saraswat Lakshmi D.,
Kenny Janis M.,
Davis Sharon K.,
Justice Joseph B.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580181016
Subject(s) - chemistry , normetanephrine , homovanillic acid , metanephrine , deuterium , tyramine , derivative (finance) , dopamine , norepinephrine , chromatography , phenethylamines , stereochemistry , urine , biochemistry , medicine , serotonin , physics , receptor , quantum mechanics , financial economics , economics
The preparation of deuterium labelled catecholamines and their metabolites is described. The procedures involve simple treatment of the compounds in DC1/D 2 O solution. Mass spectra of these labelled compounds — as their PFP or TFA derivative — are presented. The relative intensity of ions suitable for selective ion monitoring are given for each compound. Results are presented concerning ease or difficulty of deuteration. The compounds studied include dopamine, tyramine, 3‐methoxytyramine, norepinephrine, metanephrine, normetanephrine, homovanillic acid and dihydroxyphenylacetic acid.