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Preparation of deuterium labelled α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA)
Author(s) -
Lauridsen Jørn,
Honoré Tage
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580181012
Subject(s) - chemistry , decarboxylation , deuterium , hydrolysis , ampa receptor , organic chemistry , catalysis , amino acid , medicinal chemistry , glutamate receptor , biochemistry , physics , receptor , quantum mechanics
The preparation of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid (AMPA) with deuterium α to the carboxylic acid group (2) and in the exocyclic methyl group (5), respectively, are described. The deuterium labelled AMPA (2) was synthesized by hydrolysis and decarboxylation of the corresponding di‐ester (1), whereas the deuterium labelled AMPA (5) was prepared via a catalytic deuteration of the bromoderivative (3).