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Labelled psoralens. Synthesis of 4′‐aminomethyltrioxsalen‐ 3‐t
Author(s) -
Liebman Arnold A.,
Delaney Charles M.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180810
Subject(s) - chemistry , hydrogenolysis , halogenation , phthalimide , moiety , tritium , derivative (finance) , deuterium , specific activity , radiochemistry , medicinal chemistry , stereochemistry , organic chemistry , catalysis , enzyme , physics , quantum mechanics , nuclear physics , financial economics , economics
Bromination of 4′‐phthalimidomethyltrioxsalen (3) provided the 3‐monobromo derivative ( 4 ) which on hydrogenolysis with either deuterium or tritium provided the corresponding labelled derivatives 5 and 6 . Removal of the phthalimide moiety from 6 produced the title compound ( 9 ) having specific activity of 7.46 Ci/mmole.