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Potential drugs labelled with 14 C. I. The synthesis of 3‐benzylamino‐5, 6‐dihydro‐8, 9‐dimethoxy‐imidazo [5,1‐a] isoquinoline hydrochloride
Author(s) -
Zólyomi G.,
Koltai E.,
Bánfi D.,
Harsányi K.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180608
Subject(s) - isoquinoline , chemistry , hydrochloride , ring (chemistry) , imidazole , stereochemistry , medicinal chemistry , halogen , organic chemistry , alkyl
3‐Benzylamino‐8, 9‐dimethoxy‐5, 6‐dihydro‐imidazo‐ [5,1‐a] isoquinoline hydrochloride was labelled with 14 C in two different positions: In one case the 14 C was built into the position 2 of the imidazole ring, in the other case into the position 3 of the isoquinoline ring. In the first case the mechanism of the halogen‐cyano exchange reaction of 1‐chloromethyl‐5, 6‐dimethoxy‐3, 4‐dihydro‐isoquinoline was investigated by tracer experiments.