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The preparation of aromatic astatine compounds through aromatic mercury compounds part II: Astatination of pyrimidines and steroids
Author(s) -
Visser Gerard W. M.,
Diemer Eduard L.,
Kaspersen Frans M.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180606
Subject(s) - chemistry , uracil , mercury (programming language) , cytosine , nucleotide , dna , in vitro , organic chemistry , radiochemistry , biochemistry , computer science , gene , programming language
Several 211 At‐astatopyrimidines (5‐At‐uracil, 5‐At‐cytosine and their nucleosides and nucleotides including DNA and RNA) have been synthesized in high radiochemical yields by reaction of 211 At/I 2 and the corresponding chloromercury compounds. Also some astato‐steroids (6‐At‐cholesterol and 2‐ and 4‐astatoestradiol) have been prepared by this method. The stability in vitro was determined under different conditions in comparison with the analogous iodo compounds.