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Preparation of tritiated 2,4‐diamino‐5‐adamantyl‐6‐methylpyrimidine
Author(s) -
Zakrzewski Sigmund F.,
Evans E. Anthony
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180509
Subject(s) - chemistry , tritium , moiety , sephadex , tritiated water , radiochemistry , adamantane , nuclear chemistry , organic chemistry , medicinal chemistry , stereochemistry , physics , nuclear physics , enzyme
Tritium labeled 2,4‐diamino‐5‐adamantyl‐6‐methylpyrimidine was prepared by a platinum metal catalyzed tritium exchange for 4 hr at 70°. The crude material was purified on a Sephadex G‐25 column and converted to its water soluble ethanesulfonate salt. The analysis of the purified material revealed that 43% of the tritium was located in the 6‐methyl group and the remainder in the adamantane moiety of the molecule.