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Preparation of deuterium‐labeled rutin by hydrogen exchange reaction
Author(s) -
Hiraoka K.,
Miyamoto T.,
Baba S.,
Furuta T.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180502
Subject(s) - rutin , chemistry , deuterium , hydrogen , hydrogen–deuterium exchange , organic chemistry , nuclear chemistry , inorganic chemistry , radiochemistry , nuclear physics , antioxidant , physics
Abstract Preparation of deuterium‐labeled rutin by hydrogen exchange reaction under alkaline condition is described. Hydrogens at positions 2′, 5′ and 6′ of rutin were replaced with deuteriums only on heating, while hydrogens at positions 6 and 8 were readily replaced at room temperature. On the basis of these findings rutin‐2′, 5′, 6′, 6, 8‐d 5 was first prepared and then treated with alkaline water at room temperature to obtain rutin labeled with deuteriums at positions 2′, 5′ and 6′.