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Preparation of [7,7‐ 2 H 2 ] lithocholic acid
Author(s) -
Phillipou G.,
Seaborn C. J.,
Butler R. N.
Publication year - 1981
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580180417
Subject(s) - chemistry , lithocholic acid , yield (engineering) , deoxygenation , hydrolysis , reagent , deuterium , acid hydrolysis , organic chemistry , radiochemistry , bile acid , biochemistry , catalysis , materials science , physics , quantum mechanics , metallurgy
Abstract Electrochemical deoxygenation of methyl 7‐keto‐lithocholate using deuterated reagents, followed by base hydrolysis is shown to give [7,7‐ 2 H 2 ] lithocholic acid in 60% overall yield and 86% 2 H 2 isotopic purity.