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Synthesis and characterization of 5‐methyl‐1‐phenyl‐3,4,5,6‐tetrahydro‐1H‐2,5‐benzoxazocine‐1,3,4,6‐ 13 C hydrochloride (Nefopam‐ 13 C hydrochloride)
Author(s) -
Bunker James E.,
Newmark Richard A.
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170511
Subject(s) - chemistry , hydrochloride , yield (engineering) , phthalic acid , alcohol , analgesic , carbon 13 nmr , medicinal chemistry , organic chemistry , medicine , materials science , metallurgy , pharmacology
Nefopam hydrochloride (I), an analgesic agent, was labelled with carbon‐13 at C‐1,3,4 and 6 positions for metabolic studies. The starting materials for the synthesis included commercially available phthalic acid‐carboxyl‐ 13 C 1 (II) and 2‐methylaminoethyl‐1,2‐ 13 C 2 alcohol. The extent of isotope enrichment was determined by nuclear magnetic resonance and mass spectroscopy. The overall yield of I was 34% from phthalic acid‐carboxyl‐ 13 C.