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Preparation of 17β‐hydroxy‐[1ξ,2ξ‐ 3 H 2 ]4,6‐Androstadien‐3‐one
Author(s) -
Taylor Clinton A.,
Danzo Benjamin J.,
Smith Howard E.
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170504
Subject(s) - chemistry , tritium , benzene , chromatography , thin layer chromatography , palladium , high performance liquid chromatography , carbon 14 , nuclear chemistry , radiochemistry , organic chemistry , catalysis , nuclear physics , quantum mechanics , physics
17β‐Hydroxy‐[1ξ,2ξ‐ 3 H 2 ]4,6‐androstadien‐3‐one was prepared by the selective reduction of 17β‐hydroxy‐1,4,6‐androstatrien‐3‐one in benzene with tritium over 5% palladium on carbon. After purification by thin layer chromatography and high pressure liquid chromatography, the specific activity was at least 37 Ci/mmol, and the radiochemical purity was greater than 96%.