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Mit γ‐Emittern Markierte Steroide ‐ Ester des östradiols und cholestenols mit [ 103 Ru]‐ruthenocencarbon‐säure
Author(s) -
Hoffmann K.,
Rießelmann B.,
Wenzel M.
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170313
Subject(s) - chemistry , ruthenocene , ferrocene , yield (engineering) , chloride , medicinal chemistry , nuclear chemistry , organic chemistry , electrochemistry , materials science , electrode , metallurgy
Radioactive esters of estradiol and cholestenol with ruthenocene‐carboxylic acid were prepared. In case of the estradiol esters there had been exchange of Fe in the corresponding ferrocene compounds with 103 RuCl 3 resulting in poor yield only. Good radiochemical yields were obtained by exchanging 103 Ru for Fe in (2‐chlorobenzoyl)ferrocene and synthesis of the esters by reaction of estradiol with [ 103 Ru] ruthenocenecarboxylic acid chloride generated from (2‐chlorobenzoyl)ruthenocene. High specific activities of estradiol esters for biochemical studies were achieved after separation of the ferrocene and ruthenocene esters by HPLC.