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Synthesis of 5′, 5′‐Dideuterated nucleoside and nucleotide anabolites of 6‐Mercaptopurine
Author(s) -
Jardine Ian,
Weidner Mark M.
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170310
Subject(s) - riboside , chemistry , nucleotide , moiety , mass spectrometry , nucleoside , mercaptopurine , ribose , stereochemistry , chemical ionization , phosphate , chromatography , ion , biochemistry , ionization , organic chemistry , medicine , gene , enzyme
6‐Mercaptopurine riboside, 6‐methylmercaptopurine riboside, 6‐mercaptopurine riboside‐5′‐phosphate and 6‐methylmercaptopurine riboside‐5′‐phosphate were synthesized with 2 deuteriums in the ribose moiety at the 5′‐position so as to act as internal standards for the quantitation of these anabolites of 6‐mercaptopurine from biological media by gas chromatography‐selected ion monitoring mass spectrometry with chemical ionization.