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Synthesis and quality control of long‐chain 18 F‐fatty acids
Author(s) -
Knust Ernst Joachim,
Schüller Manfred,
Stöcklin Gerhard
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170306
Subject(s) - chemistry , decanoic acid , stearic acid , hydrolysis , nucleophile , alkaline hydrolysis , fatty acid , acetamide , trifluoroacetic acid , organic chemistry , nuclear chemistry , catalysis
Abstract Introduction of fluorine‐18 into various positions of long‐chain fatty acids is described. The potential heart and liver radiopharmaceuticals 16‐ 18 F‐hexadecanoic acid, 17‐ 18 F‐heptadecanoic acid, 2‐ 18 F‐, and (9,10)‐ 18 F‐stearic acid have been prepared by nucleophilic F‐for‐Br exchange in the melt of the corresponding bromofatty acid methylesters in acetamide, followed by alkaline or acid hydrolysis. In the case of 17‐ 18 F‐hepta‐decanoic acid saturation yields of about 30% have been obtained at an optimum reaction temperature of 150 °C and about 1 mg of KF‐carrier.