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Synthesis of lidocaine‐d 3
Author(s) -
Hignite Charles E.,
Tschanz Christian,
Huffman David H.,
Azarnoff Daniel L.
Publication year - 1980
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580170205
Subject(s) - chemistry , lidocaine , deuterium , yield (engineering) , chemical synthesis , radiochemistry , stereochemistry , combinatorial chemistry , in vitro , nuclear physics , anesthesia , biochemistry , thermodynamics , medicine , physics
A simple two step synthetic procedure has been developed for the preparation of deuterated lidocaine. The deuterium was incorporated into the 6′‐methyl group which is a metabolically stable position. The overall yield of the synthetic procedure was 41.3%.