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The labeling of 4‐alkylamino‐iodoquinolines with radioactive iodine by isotopic exchange
Author(s) -
Bakker Cees N. M.,
Kaspersen Frans M.
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160614
Subject(s) - chemistry , iodide , radiochemistry , iodine , nucleophile , radioactive iodine , sodium iodide , phosphate , inorganic chemistry , organic chemistry , catalysis , medicine , thyroid
4‐alkylamino‐iodoquinolines can be labeled as their phosphate salts in high yields and in a short period of time by nucleophilic exchange in a melt with radioactive iodide. The iodide must be free of NaCl and reducing agents.