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Synthesis of tritiated bromobenzene derivatives
Author(s) -
Hanzlik Robert P.,
Wiley Robert A.,
Gillesse Timothy J.
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160404
Subject(s) - bromobenzene , chemistry , salt (chemistry) , radiochemistry , organic chemistry , nuclear chemistry , catalysis
The synthesis of 3 H‐bromobenzene, 3 H‐ o ‐bromotoluene, 3 H‐ o ‐bromobenzonitrile, 3 H‐ o ‐bromobenzotrifluoride is reported. The method involves exchange‐tritiation of the appropriate anilines in heptafluorobutyric acid, followed by diazotization and either reduction or Sandmeyer coupling of the diazonium salt.