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A convenient synthesis of carboxyl‐labelled ricinoleic acid
Author(s) -
McChesney James D.,
Fraher Phil
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160402
Subject(s) - ricinoleic acid , chemistry , ether , pyrolysis , organic chemistry , carbon dioxide , polymer chemistry , castor oil
The exchange reaction of carboxyl groups with labelled carbon dioxide has been utilized for the preparation of carboxyl labelled ricinoleic acid. The thermal instability of ricinoleic acid is overcome by pyrolysis of the t‐butyl ether‐t‐butyl ester in the presence of labelled carbonate. The developed procedure should be appropriate to other thermally unstable substrates.