Premium
11 C‐Labelled radiopharmaceuticals: Synthesis and high pressure liquid chromatography of nicotinic‐ 11 C acid amide
Author(s) -
Machulla H.J.,
Dutschka K.
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160208
Subject(s) - chemistry , amide , chromatography , column chromatography , nicotinic agonist , high performance liquid chromatography , lithium (medication) , organic chemistry , biochemistry , receptor , medicine , endocrinology
Starting with 11 CO 2 , [carboxyl‐ 11 C]‐nicotinic acid amide was synthesized via 3‐pyridyl‐lithium in practically carrier‐free amounts within 60 minutes. Overall radiochemical yields between 20% and 30% were obtained. Identification and purification of the labelled product was carried out by high pressure liquid chromatography using water as eluent.