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Preparation of [1‐ 14 C]‐ and [9,10‐ 3 H]‐ Trans ‐9‐Octadecenoic Acids from the Corresponding cis ‐Compounds
Author(s) -
Christie William W.
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160205
Subject(s) - chemistry , yield (engineering) , nitrous acid , toluene , silver nitrate , cis–trans isomerism , double bond , medicinal chemistry , stereochemistry , organic chemistry , chromatography , materials science , metallurgy
Abstract [1‐ 14 C]‐Trans‐9‐octadecenoic acid was obtained in 60 per cent overall yield and [9,10‐ 3 H]‐trans‐9‐octadecenoic acid in 30 percent yield by stereomutation of the double bonds in the corresponding cis ‐compounds with nitrous acid in toluene. The products were purified by silver nitrate chromatography and contained no detectable positional isomers.