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Synthesis of iodine‐131 labelled 6β‐iodomethyl‐19‐norcholest‐5(10)‐en‐3α‐ol and 19‐iodocholest‐5‐en‐3α‐ol
Author(s) -
Komatsu, H.,
Maeda M.,
Morita H.,
Shimoirisa H.,
Kojima M.
Publication year - 1979
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580160204
Subject(s) - chemistry , sodium iodide , iodine , iodide , acetone , hydrolysis , sulfonate , toluene , medicinal chemistry , sodium , radiochemistry , sodium acetate , nuclear chemistry , organic chemistry
Abstract 6β‐Iodomethyl‐19‐norcholest‐5(10)‐en‐3α‐ol (VI) was synthesized by the homoallylic rearrangement of 19‐iodocholest‐5‐en‐3α‐ol (V), which was obtained by the hydrolysis of 19‐iodocholest‐5‐en‐3α‐ol acetate derived from the displacement of cholest‐5‐ene‐3α,19‐diol 3‐acetate 19‐toluene‐p‐sulfonate with sodium iodide in isopropanol. The radioiodinated V and VI were prepared by isotope exchange with sodium iodide‐I‐131 in acetone.