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Synthesis of taurine‐ 13 C 2 . A potential probe for human 13 CO 2 breath tests
Author(s) -
Andresen B. D.,
Davis F. T.,
Toskes P. P.,
King C. E.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150188
Subject(s) - taurine , chemistry , chromatography , derivative (finance) , biochemistry , amino acid , financial economics , economics
The synthesis of a 2% mixture of taurine‐ 13 C 2 , in nonlabelled taurine is presented. Using 1, 2‐dibromoethane‐ 13 C 2 , labelled taurine was prepared in two steps as a new and potentially useful probe for 13 CO 2 breath tests in the diagnosis of intestinal malabsorption. Unique analytical data are presented, including gas chromatographic and mass spectral data of a derivative of taurine, N‐carbobenzyloxytaurine amide. These new results were essential for the characterization and determination of isotopic enrichment of the 2% labelled taurine probe. Considerations for human feeding experiments with this stable, isotopically labelled mixture are also discussed.