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Synthesis of 1‐(tetrahydrofuran‐2‐yl)‐5‐fluorouracil‐2‐ 14 C) (ftorafur‐2‐ 14 C)
Author(s) -
Manning Steven J.,
Cohen Arthur M.,
Townsend Leroy B.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150186
Subject(s) - chemistry , tetrahydrofuran , fluorouracil , pharmacology , organic chemistry , chemotherapy , medicine , solvent
The synthesis of 1‐(tetrahydrofuran‐2‐yl)‐5‐fluorouracil‐2‐ 14 C (Ftorafur‐2‐ 14 C) has been accomplished by the condensation of 5‐fluorouracil‐2‐ 14 C and 2‐chlorotetrahydrofuran using a procedure developed in our laboratory.