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Acid catalyzed tritium exchange of activated aromatic protons
Author(s) -
Muccino Richard R.,
Serico Lucia
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150161
Subject(s) - chemistry , tritium , catalysis , acetic acid , reserpine , reagent , chloride , radiochemistry , tritium illumination , specific activity , nuclear chemistry , inorganic chemistry , organic chemistry , nuclear physics , medicine , physics , enzyme , endocrinology
A technique is described for the acid catalyzed tritium exchange of activated aromatic protons using acetic acid‐ 3 H/ tritium chloride. In the two examples reported, specific activities of 0.5 Ci/mmol were obtained for propranolol and 1.73 Ci/mmol for reserpine. The reagent mixture was found to be very effective and easily manipulated under vacuum.