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Alumina catalyzed tritium exchange of enolizable hydrogens
Author(s) -
Muccino Richard R.,
Serico Lucia
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150160
Subject(s) - chemistry , tritium , labelling , catalysis , radiochemistry , combinatorial chemistry , inorganic chemistry , organic chemistry , nuclear physics , biochemistry , physics
A technique for the alumina catalyzed tritium exchange of enolizable hydrogens is described. In the two examples reported, the labelling of α‐bromo‐p‐azidoacetophenone and haloperidol, specific activities of 0.96 and 0.315 Ci/nmol, respectively, were obtained. The procedure was found to be extremely mild and required no purification techniques.