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Synthesis of tritium labeled phenylephrine
Author(s) -
Teng Lina,
Bruce Robert B.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150137
Subject(s) - chemistry , hydrogenolysis , yield (engineering) , hydrochloride , phenylephrine , tritium , hydrolysis , dimethyl sulfate , sulfate , alkaline hydrolysis , organic chemistry , nuclear chemistry , chromatography , catalysis , medicine , materials science , physics , blood pressure , nuclear physics , metallurgy , radiology
Abstract An improved method for small scale synthesis of phenyl‐ephrine hydrochloride is described. 5‐[3‐(phenylmethoxy)phenyl]‐2‐oxazolidinone was methylated with dimethylsulfate‐methyl‐ 3 H 3 . The resulting compound was converted to phenylephrine hydrochloride by alkaline hydrolysis followed by hydrogenolysis. The radiochemical yield was over 50% based on dimethyl sulfate.