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Synthesis of 14 C‐labeled N ‐nitrosobis (2‐hydroxypropyl) amine
Author(s) -
Kupper R.,
Nagel D.,
Gingell R.,
Brunk G.
Publication year - 1978
Publication title -
journal of labelled compounds and radiopharmaceuticals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.432
H-Index - 47
eISSN - 1099-1344
pISSN - 0362-4803
DOI - 10.1002/jlcr.2580150123
Subject(s) - chemistry , amine gas treating , yield (engineering) , hamster , lactic acid , carcinogen , stereochemistry , medicinal chemistry , organic chemistry , medicine , bacteria , materials science , biology , metallurgy , genetics
Abstract N‐Nitrosobis(2‐hydroxypropyl)amine (BHP), a potent pancreatic carcinogen in the Syrian golden hamster, was synthesized with the 14 C‐label in the 1‐position of one of the propyl groups. Starting with lactic‐1‐ 14 C acid, BHP was prepared utilizing a four‐step reaction sequence, with an overall yield of 45%. Intermediate purification was not necessary.